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Rabbit Anti-Calretinin/PE-Cy3 Conjugated antibody (bs-0062R-PE-Cy3)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-0062R-PE-Cy3
英文名称1 Rabbit Anti-Calretinin/PE-Cy3 Conjugated antibody
中文名称 PE-Cy3标记的钙结合蛋白抗体
别    名 29 kDa calbindin; CAB 29; CAB29; CAL 2; CAL2; CALB 2; CALB2; Calbindin 2 29kDa; Calbindin 2; Calbindin D29K; Calbindin2; CR; CALB2_HUMAN; Calretinin.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 神经生物学  结合蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 29kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Calretinin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Calretinin is a calcium-binding protein which is abundant in auditory neurons. It belongs to the calbindin family. Calbindin 2 (calretinin), closely related to calbindin 1, is an intracellular calcium-binding protein belonging to the troponin C superfamily. Calbindin 1 is known to be involved in the vitamin-D-dependent calcium absorption through intestinal and renal epithelia, while the function of neuronal calbindin 1 and calbindin2 is poorly understood. The sequence of the calbindin 2 cDNA reveals an open reading frame of 271 codons coding for a protein of 31,520 Da, and shares 58% identical residues with human calbindin1.

Function:
Calretinin is a calcium-binding protein which is abundant in auditory neurons.

Tissue Specificity:
Brain.

Similarity:
Belongs to the calbindin family.
Contains 6 EF-hand domains.

Database links:

Entrez Gene: 396255 Chicken

Entrez Gene: 794 Human

Entrez Gene: 12308 Mouse

Entrez Gene: 117059 Rat

Entrez Gene: 393684 Zebrafish

Omim: 114051 Human

SwissProt: P07090 Chicken

SwissProt: P22676 Human

SwissProt: Q08331 Mouse

SwissProt: P47728 Rat

Unigene: 106857 Human

Unigene: 2755 Mouse

Unigene: 10321 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


钙结合蛋白(Calretinin,CR)主要存在于神经组织中,近10%的腺癌可以表达此蛋白的局部染色阳性,而绝大多数的间皮瘤为阳性表达,因此它是诊断间皮瘤的一个有用的标记物 。
钙结合蛋白是平滑肌和非肌性调控蛋白。它可以与肌动蛋白、肌球蛋白、原肌球蛋白和钙调素相互作用。
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