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Rabbit Anti-LYRIC/PE-Cy3 Conjugated antibody (bs-2231R-PE-Cy3)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-2231R-PE-Cy3
英文名称1 Rabbit Anti-LYRIC/PE-Cy3 Conjugated antibody
中文名称 PE-Cy3标记的星形胶质细胞升高基因1抗体
别    名 Astrocyte elevated gene 1; AEG 1; AEG1; MTDH; AEG1; AEG-1; LYRIC; Protein LYRIC; Lysine-rich CEACAM1 co-isolated protein; 3D3/LYRIC; Metastasis adhesion protein; Metadherin; Astrocyte elevated gene-1 protein; 3D3; Lysine rich CEACAM1 associated protein  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  信号转导  上皮细胞  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, )
产品应用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 64kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human AEG-1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
LYRIC is a type II membrane protein, the precise role of which has yet to be defined. It is expressed in breast and prostate carcinoma and is a potential mediator of lung metastasis. It has also been found in mouse Purkinje neurons and cerebellum. In epithelial cells it is recruited to tight junctions (TJ) during the maturation of the TJ complexes. LYRIC co-localizes with beta-catenin in normal and tumour tissues.

Function:
Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.

Subunit:
Interacts with BCIPP, CREBBP/CBP and RELA/p65.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Cell junction, tight junction. Nucleus, nucleolus . Cytoplasm, perinuclear region. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain. TNF-alpha causes translocation from the cytoplasm to the nucleus.

Tissue Specificity:
Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.

Database links:

Entrez Gene: 509788 Cow

Entrez Gene: 92140 Human

Entrez Gene: 67154 Mouse

Entrez Gene: 170910 Rat

Omim: 610323 Human

SwissProt: Q86UE4 Human

SwissProt: Q80WJ7 Mouse

SwissProt: Q9Z1W6 Rat

Unigene: 377155 Human

Unigene: 130883 Mouse

Unigene: 6864 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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