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Rabbit Anti-IL3R alpha/AF555 Conjugated antibody (bs-2600R-AF555)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-2600R-AF555
英文名称 Anti-IL3R alpha/AF555
中文名称 AF555标记的白介素3受体a链抗体
别    名 IL-3R alpha; IL3R alpha; Interleukin-3 receptor subunit alpha precursor; CD 123; CD123; CD123 antigen; hIL3Ra; IL 3 receptor subunit alpha; IL 3R alpha; IL 3R; IL 3R subunit alpha; IL3 receptor subunit alpha; IL3R alpha; IL3R; IL3RAY; IL3RX; IL3RY; Interleukin 3 receptor alpha; Interleukin 3 receptor, alpha (low affinity); Interleukin-3 receptor; MGC34174; IL3RA_HUMAN.   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, 
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 40kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IL-3R alpha
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]

Function:
This is a receptor for interleukin-3.

Subunit:
Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the type I cytokine receptor family. Type 5 subfamily.

Database links:

Entrez Gene: 3563 Human

Omim: 308385 Human

Omim: 430000 Human

SwissProt: P26951 Human

Unigene: 632790 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

白细胞介素3受体α(IL-3Rα)又称CD123,是造血生长因子受体家族成员,CD123是未分化白血病干细胞的特异标志.在细胞信号转导、细胞凋亡及血液肿瘤发生中起重要作用.
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