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Rabbit Anti-CD244/Cy5.5 Conjugated antibody (bs-2470R-Cy5.5)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-2470R-Cy5.5
英文名称1 Rabbit Anti-CD244/Cy5.5 Conjugated antibody
中文名称 Cy5.5标记的CD244抗体
别    名 NKR2B4; SLAMF4; natural killer cell receptor 2B4 isoform 2 precursor; 2B4 ; C9.1; CD244 antigen; CD244 molecule natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; F730046O15Rik; h2B4; Ly90; NAIL; Natural killer cell activation-inducing ligand; Natural killer cell receptor 2B4; NK cell activation inducing ligand; NK cell activation inducing ligand NAIL; NK cell type I receptor protein 2B4; Nmrk; Non-MHC restricted killing associated; OTTHUMP00000027884; p38; SLAM family, member 4.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  干细胞  细胞粘附分子  细胞表面分子  自然杀伤细胞  淋巴细胞  t-淋巴细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,  (predicted: Mouse, Rat, )
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD244
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Function:
Modulate other receptor-ligand interactions to enhance leukocyte activation.

Subunit:
Interacts with CD48. Following phosphorylation, it is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. Binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2.

Subcellular Location:
Membrane; Single-pass type I membrane protein (Potential).

Tissue Specificity:
Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed not only in NK cells, but also on monocytes and basophils.

Similarity:
Contains 2 Ig-like (immunoglobulin-like) domains.

Database links:

Entrez Gene: 51744 Human

Entrez Gene: 18106 Mouse

Entrez Gene: 64025 Rat

Omim: 605554 Human

SwissProt: Q9BZW8 Human

SwissProt: Q07763 Mouse

SwissProt: Q9JLM2 Rat

Unigene: 157872 Human

Unigene: 2299 Mouse

Unigene: 113760 Rat

Unigene: 53994 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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