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Rabbit Anti-hCG receptor /PE-Cy5 Conjugated antibody (bs-0984R-PE-Cy5)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-0984R-PE-Cy5
英文名称1 Rabbit Anti-hCG receptor /PE-Cy5 Conjugated antibody
中文名称 PE-Cy5标记的促黄体生成素受体抗体
别    名 LHCGR; Gonadotropin receptor; CGR; hCG receptor; FLJ41504; Gpcr19-rs1; GTHR-II; HHG; LCGR; LGR2; LH-R; LHR; LH/CG R; LH/CG-R; LH RECEPTOR; LH/CGR; LHR; LHRHR; LSH R; LSH-R; LSHR_MOUSE; Luteinizing hormone receptor; Luteinizing hormone/choriogonadotropin receptor; luteinizing hormone/choriogonadotropin receptor; Lutropin choriogonadotropic hormone receptor; Lutropin choriogonadotropic receptor; Lutropin-choriogonadotropic hormone receptor; ULG5.   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 神经生物学  生长因子和激素  内分泌病  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Mouse, Rat, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 76kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse CG Receptor
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq]

Function:
Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Gonadal and thyroid cells.

DISEASE:
Familial male precocious puberty (FMPP) [MIM:176410]: In FMPP the receptor is constitutively activated. Note=The disease is caused by mutations affecting the gene represented in this entry.
Luteinizing hormone resistance (LHR) [MIM:238320]: An autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Contains 6 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain.

Database links:

Entrez Gene: 3973 Human

Entrez Gene: 25477 Rat

Omim: 152790 Human

SwissProt: P22888 Human

SwissProt: P16235 Rat

Unigene: 468490 Human

Unigene: 11216 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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