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Rabbit Anti-LAR/Gold Conjugated antibody (bs-11530R-Gold)
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说 明 书: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包装/询价
产品编号 bs-11530R-Gold
英文名称 Rabbit Anti-LAR/Gold Conjugated antibody
中文名称 胶体金标记的受体蛋白酪氨酸磷酸酶F抗体
别    名 LAR; LAR protein; LARFN5C; PTPRF; LARS; LCA homolog; Leukocyte antigen related (LAR) PTP receptor; Leukocyte antigen related; Leukocyte antigen related PTP receptor; Leukocyte antigen related tyrosine phosphatase; Leukocyte common antigen related; Protein Tyrosine Phosphatase Receptor Type F; Protein tyrosine phosphatase receptor type F polypeptide; Ptprf; PTPRF protein; PTPRF_HUMAN; Receptor linked protein tyrosine phosphatase LAR; Receptor type tyrosine protein phosphatase F; Receptor type tyrosine protein phosphatase F precursor; Receptor-type tyrosine-protein phosphatase F.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul(10nm  15nm  35nm
研究领域 肿瘤  细胞生物  神经生物学  信号转导  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
产品应用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 210kDa
性    状 Lyophilized or Liquid
浓    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PTPRF (30-100aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存条件 Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
产品介绍 background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Function:
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity.
The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.

Subunit:
Interacts with GRIP1. Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with INSR.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
Contains 8 fibronectin type-III domains.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 2 tyrosine-protein phosphatase domains.

Database links:

Entrez Gene: 5792 Human

Entrez Gene: 19268 Mouse

Entrez Gene: 360406 Rat

Entrez Gene: 12072 Cow

Omim: 179590 Human

SwissProt: P10586 Human

SwissProt: Q5T021 Human

SwissProt: Q5T022 Human

SwissProt: Q86WS0 Human

SwissProt: A2A8L5 Mouse

SwissProt: Q9EQ17 Mouse

SwissProt: Q64604 Rat

Unigene: 272062 Human

Unigene: 29855 Mouse

Unigene: 11386 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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