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Rabbit Anti-CNTN5/AP Conjugated antibody (bs-11453R-AP)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-11453R-AP
英文名称1 Rabbit Anti-CNTN5/AP Conjugated antibody
中文名称 碱性磷酸酶(AP)标记的轴突蛋白5抗体
别    名 Contactin5; Contactin 5; Contactin-5; hNB 2; HNB 2s; NB 2; Neural recognition molecule NB 2; CNTN5_HUMAN; Neural recognition molecule NB-2; hNB-2.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  细胞粘附分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep, )
产品应用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 119kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Contactin 5 (801-900aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is a member of the immunoglobulin superfamily, and contactin family, which mediate cell surface interactions during nervous system development. This protein is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].

Function:
CNTN5 is a member of the immunoglobulin superfamily. Contactins mediate cell surface interactions during the development of the nervous system. CNTN5 has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons and is most likely involved in neuronal activity in the auditory system.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity:
Expressed in brain and kidney and at very low level in placenta. Not expressed in other tissues. In brain, it is highly expressed in the occipital lobe, amygdala, cerebral cortex, frontal lobe, thalamus and temporal lobe. Expressed at moderate level in the cerebellum, substantia nigra, putamen, medulla and hippocampus. Weakly expressed in the spinal cord and caudate nucleus. Weakly or not expressed in the corpus callosum.

Similarity:
Belongs to the immunoglobulin superfamily. Contactin family.
Contains 4 fibronectin type-III domains.
Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

Database links:

Entrez Gene: 53942 Human

Entrez Gene: 244682 Mouse

Entrez Gene: 114589 Rat

Omim: 607219 Human

SwissProt: O94779 Human

SwissProt: P68500 Mouse

SwissProt: P97527 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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