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Rabbit Anti-Myocardin/HRP Conjugated antibody (bs-9472R-HRP)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-9472R-HRP
英文名称 Rabbit Anti-Myocardin/HRP Conjugated antibody
中文名称 辣根过氧化物酶标记的促血管平滑肌细胞分化因子抗体
别    名 MYCD; MYCD_HUMAN; Myocardin; Myocd.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 心血管  免疫学  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
产品应用 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 103kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Myocardin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Transcriptional factor that uses the canonical single or multiple CArG boxes DNA sequence. Binds CArG boxes only in the presence of serum response factor (SRF). Acts as a cofactor of SRF and modulates SRF-target genes. Regulates the expression of a set of cardiac and smooth muscle-specific genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage.

Function:
Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis).

Subunit:
Homodimer. Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex formation. Interacts with MLLT7/FOXO4. Interacts (via C-terminal) with EP300 (via the CREB-binding domain). Interacts with HDAC4 and HDAC5 (By similarity). Interacts with MEF2C.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder, small intestine, colon, lung, placenta and uterus. Very faint expression in prostate and skeletal muscle.

Post-translational modifications:
Phosphorylation regulates negatively the intrinsic myocardin transcriptional activity.

Similarity:
Contains 3 RPEL repeats.
Contains 1 SAP domain.

Database links:

Entrez Gene: 93649 Human

Entrez Gene: 214384 Mouse

Entrez Gene: 396571 Pig

Entrez Gene: 246297 Rat

Omim: 606127 Human

SwissProt: Q8IZQ8 Human

SwissProt: Q8VIM5 Mouse

SwissProt: Q8R5I7 Rat

Unigene: 567641 Human

Unigene: 32257 Mouse

Unigene: 163103 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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