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Rabbit Anti-Gamma-taxilin/Gold Conjugated antibody (bs-0631R-Gold)
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说 明 书: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包装/询价
产品编号 bs-0631R-Gold
英文名称 Rabbit Anti-Gamma-taxilin/Gold Conjugated antibody
中文名称 胶体金标记的脂多糖相关反应蛋白5/γ-taxilin抗体
别    名 chromosome X open reading frame 15; LSR5; CXorf15; Environmental lipopolysaccharide-responding gene protein; factor inhibiting activating transcription factor 4 (ATF4)-mediated transcription; Factor inhibiting ATF4-mediated transcription antibody FIAT; Gamma-taxilin; Lipopolysaccharide-specific response protein 5; LSR5; TXLNG; TXLNG_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul(10nm  15nm  35nm
研究领域 细胞生物  干细胞  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, )
产品应用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 60kDa
性    状 Lyophilized or Liquid
浓    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Gamma-taxilin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存条件 Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
产品介绍 background:
This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].

Function:
May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.

Subunit:
Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Forms a heterodimer with ATF4 in osteoblasts.

Subcellular Location:
Nucleus membrane. Cytoplasm, cytosol.

Tissue Specificity:
Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. Expressed in brain, placenta, lung, liver, kidney and pancreas.

Similarity:
Belongs to the taxilin family.

Database links:

Entrez Gene: 353170 Mouse

SwissProt: Q8BHN1 Mouse

Unigene: 270186 Mouse

Unigene: 371732 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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