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Rabbit Anti-ATTY/FITC Conjugated antibody (bs-1907R-FITC)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-1907R-FITC
英文名称1 Rabbit Anti-ATTY/FITC Conjugated antibody
中文名称 FITC标记的细胞酪氨酸转氨酶抗体
别    名 TYROSINE AMINOTRANSFERASE; tyrosine aminotransferase; MGC37772; MGC37789; MGC37790; MGC37819; MGC37828; MGC37842; TAT; ATTY_HUMAN; L-tyrosine:2-oxoglutarate aminotransferase; TAT; Tyrosine aminotransferase; Tyrosine aminotransferase, cytosolic.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  激酶和磷酸酶  合成与降解  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Cow, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Tat
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked.

Function:
Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has no transaminase activity towards phenylalanine.

Subunit:
Homodimer (Probable).

DISEASE:
Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:276600]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.

Similarity:
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Database links:

Entrez Gene: 6898 Human

Entrez Gene: 234724 Mouse

Entrez Gene: 24813 Rat

Omim: 613018 Human

SwissProt: P17735 Human

SwissProt: Q8QZR1 Mouse

SwissProt: P04694 Rat

Unigene: 161640 Human

Unigene: 28110 Mouse

Unigene: 9947 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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