| 产品编号 | bs-1845R-PE-Cy5.5 |
| 英文名称 | Rabbit Anti-LRIG2/PE-Cy5.5 Conjugated antibody |
| 中文名称 | PE-Cy5.5标记的LRIG2抗体 |
| 别 名 | DKFZp451C181; KIAA0806; LIG2; leucine-rich repeats and immunoglobulin-like domains protein 2 precursor; LRIG2_HUMAN; UFS2; LIG-2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, ) |
| 产品应用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 117kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LRIG2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 |
background: LRIG2 is produced in all human glioma cell lines and localizes to perinuclear compartments, cytoplasmic compartments and the cell surface. It acts as a negative feedback regulator of signaling through enhanced receptor ubiquitination and accelerated intracellular degradation. LRIG2 may function as a tumour suppressor since it downregulates the expression of EGF and the related proteins ErbB-2, ErbB-3 and ErbB-4, which all inhibit cancer cells from growth, migration and invasion. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Tissue Specificity: Detected in all tissues analyzed. Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 15 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. Database links: Entrez Gene: 9860 Human Omim: 608869 Human SwissProt: O94898 Human Unigene: 448972 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. LRIG1属于LRIGs基因家族。LRIGs是新发现的一类基因，在哺乳动物体内广泛存在，目前发现该家族至少包括三个成员：LRIG1、LRIG2和LRIG3，是一类结构相似的跨膜糖蛋白，该蛋白人、鼠的同源性较高。 目前在肿瘤方面的研究较多，有研究认为：LRIG1是通过下调EGFR的表达来抑制其下游重要信号传导通路的激活而发挥抑癌作用，LRIG1在抑制肿瘤转移中具有重要作用。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
