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Rabbit Anti-BMP7/BF350 Conjugated antibody (bs-2242R-BF350)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-2242R-BF350
英文名称1 Rabbit Anti-BMP7/BF350 Conjugated antibody
中文名称 BF350标记的骨形态发生蛋白7抗体
别    名 bone morphogenetic protein 7 precursor; osteogenic protein 1; BMP-7; OP-1; BMP 7; Bone morphogenic protein 7; Eptotermin alfa; OP 1; OP1; BMP7_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  细胞凋亡  生长因子和激素  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rabbit,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 15.7/47kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BMP7
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq].

Function:
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

Subunit:
Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in the kidney and bladder. Lower levels seen in the brain.

Post-translational modifications:
Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (PubMed:17977014).

Similarity:
Belongs to the TGF-beta family.

Database links:

Entrez Gene: 477270 Dog

Entrez Gene: 655 Human

Entrez Gene: 12162 Mouse

Entrez Gene: 492315 Pig

Entrez Gene: 85272 Rat

Omim: 112267 Human

SwissProt: P18075 Human

SwissProt: P23359 Mouse

Unigene: 473163 Human

Unigene: 595 Mouse

Unigene: 18030 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

骨形态发生蛋白7(BMP-7)是转化生长因子β超家族成员,参与器官发生,细胞增殖、分化及凋亡等.
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