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Rabbit Anti-NADPH/Gold Conjugated antibody (bs-1537R-Gold)
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说 明 书: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包装/询价
产品编号 bs-1537R-Gold
英文名称1 Rabbit Anti-NADPH/Gold Conjugated antibody
中文名称 胶体金标记的还原型辅酶Ⅱ/磷酸酰胺腺嘌呤二核苷酸抗体
别    名 nicotinamide adenine dinucleotide phosphate; NADP; NADPH; TPNH; Triphosphopyridine nucleotide, reduced form;   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul(10nm  15nm  35nm
产品类型 小分子抗体 
研究领域 肿瘤  细胞生物  免疫学  信号转导  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应
产品应用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 0.833kDa
性    状 Lyophilized or Liquid
浓    度 0.4mg/ml
免 疫 原 KLH conjugated NADPH
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存条件 Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
产品介绍 background:
NDAPH (nicotinamide adenine dinucleotide phosphate) includes of Alpha-NADPH and Beta-NADPH. Beta-NADPH hase activity only. Beta-Nicotinamide adenine dinucleotide 2'-phosphate reduced tetrasodium salt or triphosphopyridine nucleotide reduced tetrasodium salt, also known as Coenzyme Ⅱ.
β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP).

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

NADPH氧化酶广泛存在于机体多个系统发挥重要的生理功能。在多种病理情况下,NADPH氧化酶可以在很多组织中催化合成大量活性氧,导致过度氧化应激,使组织细胞的功能下降。
NADPH氧化酶也是血管内皮细胞ROS产生的主要酶系,由其介导产生ROS在信息传递、基因转录、细胞生长和凋亡以及调节内皮依赖性的一氧化氮合酶脱偶联等血管舒张中的作用,使其成为血管生物学中重要的部分,NADPH氧化酶一方面与血管舒张的机能异常有关,另一方面又影响到内皮细胞的结构、粘附分子的表达、渗透、成长及迁移等功能。
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