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Rabbit Anti-LIFR/BF647 Conjugated antibody (bs-1458R-BF647)
~~~促销,代码KT202502A~~~
~~~促销,代码KT202502B~~~
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-1458R-BF647
英文名称 Rabbit Anti-LIFR/BF647 Conjugated antibody
中文名称 BF647标记的白血病抑制因子受体抗体
别    名 CD 118; leukemia inhibitory factor receptor; SWS; SJS2; STWS; CD118; LIF-R; FLJ98106; FLJ99923; LIFR; Leukemia inhibitory factor receptor alpha; LIF R; LIF receptor; LIFR_RAT.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  细胞凋亡  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,  (predicted: Mouse, Rat, Dog, Cow, )
产品应用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 117kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from the middle of rat LIFR
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:

This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene.

Function:
Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity).

Subunit:
"Heterodimer composed of LIFR and IL6ST. The heterodimer formed by LIFR and IL6ST interacts with the complex formed by CNTF and CNTFR.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 6 fibronectin type-III domains.

Database links:

Entrez Gene: 3977 Human

Entrez Gene: 16880 Mouse

Entrez Gene: 81680 Rat

Omim: 151443 Human

SwissProt: P42702 Human

SwissProt: P42703 Mouse

SwissProt: O70535 Rat

Unigene: 133421 Human

Unigene: 149720 Mouse

Unigene: 14529 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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