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Rabbit Anti-Cyclin G/Cy5.5 Conjugated antibody (bs-1389R-Cy5.5)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-1389R-Cy5.5
英文名称1 Rabbit Anti-Cyclin G/Cy5.5 Conjugated antibody
中文名称 Cy5.5标记的周期素G抗体
别    名 CCNG 1; CCNG; CCNG1; CYCG1; Cyclin G; CCNG1_HUMAN; Cyclin-G; Cyclin G1; CyclinG1; Cyclin-G1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  染色质和核信号  细胞周期蛋白  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cyclin G
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Cyclin G contains a typical N terminal cyclin box and a carboxy terminal domain sequence homologous to the tyrosine phosphorylation site of the epidermal growth factor receptor. Cyclin G2 shares 53% amino acid sequence identity with cyclin G1. Peak expression of cyclin G2 is seen in late S phase, as opposed to cyclin G1 expression, which is constitutive.

Function:
May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).

Subcellular Location:
Nucleus. DNA replication foci after DNA damage.

Tissue Specificity:
High levels in skeletal muscle, ovary, kidney and colon.

Similarity:
Belongs to the cyclin family. Cyclin G subfamily.

Database links:

Entrez Gene: 900 Human

Omim: 601578 Human

SwissProt: P51959 Human

Unigene: 79101 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Cyclin G的生物功能还没有完全清楚,他是细胞周期蛋白家族中近来发现的新成员,也是已知的唯一受到肿瘤抑制基因p53调控的细胞周期蛋白。
近年来经研究发现,Cyclin G可能有促进细胞增长的作用,在细胞增殖和神经再生中的可能起到一定的作用。
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