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Rabbit Anti-Nogo B/Cy7 Conjugated antibody (bs-1315R-Cy7)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-1315R-Cy7
英文名称1 Rabbit Anti-Nogo B/Cy7 Conjugated antibody
中文名称 Cy7标记的轴索过度生长抑制因子B抗体
别    名 reticulon-4 isoform B; RTN4; RTN4-B1; Nbla10545; RTN-X; reticulon-4A; Nogo-C; NSP; RTN-x; ASY; foocen; NSP-CL; NOGOC; RTN4-A; Reticulon-4; Nbla00271; KIAA0886; NOGOA; Reticulon-5; Foocen; NI220/250; RTN4-C; RTN4-B2; SP1507; NOGO-A; NOGOB; Nogo-B; Nogo-B/A.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 神经生物学  Alzheimer's  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse,  (predicted: Rat, Dog, Sheep, )
产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human reticulon-4 isoform B
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.

Function:
NOGO is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Adult mammalian axon regeneration is generally successful in the peripheral nervous system but poor in the central nervous system. Inhibition results from physical barriers imposed by glial scars, a lack of neurotrophic factors, and growth-inhibitory molecules associated with myelin, the insulating axon sheath. These molecules include NI35, myelin-associated glycoprotein (159460), and Nogo. Several isoforms (A-E) of NOGO exist.

Subcellular Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein. Note=Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains.

Database links:

Entrez Gene: 57142 Human

Entrez Gene: 68585 Mouse

Entrez Gene: 83765 Rat

Omim: 604475 Human

SwissProt: Q9NQC3 Human

SwissProt: Q99P72 Mouse

SwissProt: Q9JK11 Rat

Unigene: 704007 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神经生物学相关蛋白(Neurobiology)
Nogo-B蛋白是一组参与组织损伤后再生的跨膜功能蛋白,其中Nogo-B位于多种组织器官中而发挥不同的功能。目前研究发现,Nogo-B与肿瘤抑制、凋亡、神经系统再生抑制、血管内膜损伤修复等多种病理生理过程有不同程度的关系.
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