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Rabbit Anti-Syndecan-1/FITC Conjugated antibody (bs-1309R-FITC)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-1309R-FITC
英文名称1 Rabbit Anti-Syndecan-1/FITC Conjugated antibody
中文名称 FITC标记的多配体蛋白聚糖1抗体
别    名 SDC1; SDC; SYND1; Syndecan I; SyndecanI; Syndecan-I; syndecan; Sdc1; Syndecan1; AA408134; AA409076; Sstn; syn-1; CD138; CD 138; CD-138; CD138 antigen; Heparan sulfate proteoglycan fibroblast growth factor receptor; SDC 1; Syndecan1 precursor; SDC1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  神经生物学  细胞膜受体  细胞粘附分子  细胞表面分子  糖蛋白  上皮细胞  内皮细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Rat, Cow,  (predicted: Mouse, Chicken, Dog, Pig, Horse, Rabbit, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD138
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008].

Function:
Cell surface proteoglycan that bears both heparin sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.

Subunit:
Interacts with CDCP1.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form.

Post-translational modifications:
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.

Similarity:
Belongs to the syndecan proteoglycan family.

Database links:

Entrez Gene: 6382 Human

Entrez Gene: 20969 Mouse

Entrez Gene: 25216 Rat

Omim: 186355 Human

SwissProt: P18827 Human

SwissProt: P18828 Mouse

SwissProt: P26260 Rat

Unigene: 224607 Human

Unigene: 665958 Human

Unigene: 2580 Mouse

Unigene: 11176 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Syndecan1(CD138)属于Syndecans基因家族,该家族是一类细胞表面跨膜蛋白多糖 ,是膜表面粘附受体 ,参与细胞-细胞外基质之间的粘附。
CD138表达于上皮细胞、胚胎间质细胞、血管平滑肌细胞、内皮细胞和神经细胞基底膜。Syndecan-1与恶性肿瘤的发生发展、浸润及转移有关,着色于胞浆和胞膜.
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