| 产品编号 |
IHC0633H |
| 英文名称 |
Human SPINK1 Ready-To-Use IHC Kit
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| 中文名称 |
人肿瘤相关胰蛋白酶抑制剂1即用型免疫组化试剂盒 |
| 别 名 |
PCTT; PSTI; SPINK1; Spink3; TATI; TCP; Pancreatic Secretory Trypsin Inhibitor; Serine Protease Inhibitor Kazal-Type 1; Tumor-Associated Trypsin Inhibitor |
| 适用样品基质 |
FFPE tissue |
| 保存条件 |
Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 产品介绍 |
This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT) [MIM:167800]. A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP) [MIM:608189]. TCP is an idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer.
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| 产品图片 |
Immunohistochemical analysis of paraffin embedded Human pancreas tissue slide using IHC0633H (Human SPINK1 Kit).
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