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Rat Thymidylate synthase Ready-To-Use IHC Kit (IHC0545R)  
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50T/3200.00元
大包装/询价

产品编号 IHC0545R
英文名称 Rat Thymidylate synthase Ready-To-Use IHC Kit
中文名称 大鼠胸苷酸合成酶即用型免疫组化试剂盒
别    名 HST422; OK/SW-cl.29; TMS; TS; TYMS  
适用样品基质 FFPE tissue
保存条件 Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt.
产品介绍 Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

SWISS:
P04818

Gene ID:
7298

产品图片
Immunohistochemical analysis of paraffin embedded Rat spleen tissue slide using IHC0545R (Rat Thymidylate synthase Kit).
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