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SATB2 Ready-To-Use IHC Kit (IHC0506)  
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50T/3200.00元
大包装/询价

产品编号 IHC0506
英文名称 SATB2 Ready-To-Use IHC Kit
中文名称 DNA结合蛋白2即用型免疫组化试剂盒
别    名 GLSS; KIAA1034; SATB2; DNA binding protein SATB2; SATB homeobox 2  
适用样品基质 FFPE tissue
保存条件 Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt.
产品介绍 DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB2 is a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. It also acts as a docking site for several chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. SATB2 is required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes - probably by modulating BCL11B expression. It is a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex. Mutations in the gene are associate with cleft palate isolated (CPI).

SWISS:
Q9UPW6

Gene ID:
23314

产品图片
Immunohistochemical analysis of paraffin embedded Mouse brain tissue slide using IHC0506 (SATB2 Kit).
Immunohistochemical analysis of paraffin embedded Human gastric cancer tissue slide using IHC0506 (SATB2 Kit).
Immunohistochemical analysis of paraffin embedded Human brain tissue slide using IHC0506 (SATB2 Kit).
Immunohistochemical analysis of paraffin embedded Rat brain tissue slide using IHC0506 (SATB2 Kit).
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