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Human P4HB Ready-To-Use IHC Kit (IHC0488H)  
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50T/3200.00元
大包装/询价

产品编号 IHC0488H
英文名称 Human P4HB Ready-To-Use IHC Kit
中文名称 人蛋白质二硫键异构酶即用型免疫组化试剂盒
别    名 CLCRP1; DSI; ERBA2L; ERp59; GIT; P4HB; P4Hbeta; PDI; PDIA1; PDIR; PHDB; PO4DB; PO4HB; PROHB; Thbp  
适用样品基质 FFPE tissue
保存条件 Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt.
产品介绍 Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, the protein seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. It may therefore cause structural modifications of exofacial proteins. Inside the cell, PDI seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, it functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity). PDI may be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. It also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.

SWISS:
P07237

Gene ID:
5034

产品图片
Immunohistochemical analysis of paraffin embedded human renal carcinoma tissue slide using IHC0488H (Human P4HB IHC Kit).
Immunohistochemical analysis of paraffin embedded human breast cancer tissue slide using IHC0488H (Human P4HB IHC Kit).
Immunohistochemical analysis of paraffin embedded human liver tissue slide using IHC0488H (Human P4HB IHC Kit).
Immunohistochemical analysis of paraffin embedded human lung cancer tissue slide using IHC0488H (Human P4HB IHC Kit).
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