| 产品编号 |
bs-105778P |
| 英文名称 |
Recombinant Mouse IL5 Protein, N-His
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| 中文名称 |
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| 别 名 |
IL15, IL-15, Interleukin-15 |
| 理论分子量 |
15.44 kDa |
| 检测分子量 |
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| 性 状 |
Lyophilized |
| 纯 度 |
>90% as determined by SDS-PAGE. |
| 缓 冲 液 |
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 保存条件 |
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
Interleukin 5 is a cytokine produced primarily by activated T lymphocytes. It exists as an antiparallel disulfide linked homodimeric glycoprotein with 115 amino acid residues in each chain. Known also as EDF (eosinophil differentiating factor), functions predominantly as an eosinophilopoietic factor. Analysis of its crystal structure reveals a novel two domain structure, with each domain showing significant homology to the cytokine fold in GMCSF, MCSF, IL2, IL4 and growth hormone. Human and mouse IL5 have 70% amino acid sequence homology.
白细胞介素-5（IL-5）的表达对嗜酸粒细胞（EOS）有浸润聚集的作用，目前多用变态反应方面的研究。
支气管哮喘的重要特征主要是慢性非特异性炎症改变，其病因与发病机制十分复杂，白介素5在支气管哮喘发病机理上，近年来受到了很大关注。
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