| 产品编号 | bs-105754P |
| 英文名称 | Recombinant Human PTPN2 Protein, N-His |
| 中文名称 | |
| 别 名 | Tyrosine-protein phosphatase non-receptor type 2, TCPTP, T-cell protein-tyrosine phosphatase, PTPT, PTPN2 |
| 理论分子量 | 32.34 kDa |
| 检测分子量 | |
| 性 状 | Lyophilized |
| 纯 度 | >90% as determined by SDS-PAGE. |
| 缓 冲 液 | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011] SWISS: P17706 Gene ID: 5771 去磷酸化受体蛋白酪氨酸激酶的非受体型酪氨酸特异性磷酸酶，包括INSR、EGFR、CSF1R、PDGFR。在细胞核或细胞质中也去磷酸化非受体蛋白酪氨酸激酶，如JAK1、JAK2、JAK3、Src家族激酶、STAT1、STAT3和STAT6。能够负调控许多信号通路和生物过程，如造血，炎症反应，细胞增殖和分化，葡萄糖稳态。在免疫系统的发育中起着多方面的重要作用，通过FYN和LCK的去磷酸化来控制T细胞的分化和活化，在T细胞受体信号转导中发挥作用。去磷酸化CSF1R，负调控其下游信号和巨噬细胞分化。通过细胞质激酶 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
