| 产品编号 | bs-105087P |
| 英文名称 | Recombinant Human ERBB4/Her4 Protein, N-Fc |
| 中文名称 | |
| 别 名 | HER4; Tyrosine kinase-type cell surface receptor HER4; p180erbB4; s80HER4; ERBB4; 4ICD; Receptor tyrosine-protein kinase erbB-4; Proto-oncogene-like protein c-ErbB-4; E4ICD |
| 克 隆 号 | |
| 理论分子量 | 98.36 kDa |
| 性 状 | Lyophilized |
| 纯 度 | >90% as determined by SDS-PAGE. |
| 缓 冲 液 | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]. SWISS: Q15303 Gene ID: 2066 细胞膜受体（Membrane Receptors) c-erbB-4蛋白过去一直为乳腺癌基因研究的主要方向，研究乳腺癌组织学分级及术后生存期的关系。目前认为他与细胞增殖活性和激素受体有一定的关联，有学者将c-erbB-4蛋白研究用于神经内分泌蛋白为主。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
