| 产品编号 | bs-105033P |
| 英文名称 | Recombinant Human TDGF1/CRIPTO Protein, C-His |
| 中文名称 | |
| 别 名 | Cripto-1 growth factor; Teratocarcinoma-derived growth factor 1; TDGF1; CRIPTO; Epidermal growth factor-like cripto protein CR1; CRGF |
| 克 隆 号 | |
| 理论分子量 | 17.13 kDa |
| 性 状 | Lyophilized |
| 纯 度 | >90% as determined by SDS-PAGE. |
| 缓 冲 液 | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. SWISS: P13385 Gene ID: 6997 Cripto-1是表皮生长因子-Cripto-FRL-Criptic(EGF-CFC)家族成员之一, 属于转化生长细胞TGF-β蛋白家族及Nodal蛋白质的共同受体。Cripto蛋白对于胚胎的发育占有非常重要的地位。 Cripto-1在人类的多种肿瘤如结肠癌、乳腺癌、卵巢癌、胰腺癌等中高表达，可激活P13K/Akt/GSK-3βc-Src和ras/raf/MAPK信号通路,介导细胞增殖和抑制细胞凋亡，Cripto蛋白的单细胞繁殖抗体，可以有效抑制一些癌细胞的生长。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
