| 产品编号 | bs-104670P |
| 英文名称 | Recombinant Human CD335/NCR1/NKp46 Protein, C-Fc |
| 中文名称 | |
| 别 名 | LY94; Natural cytotoxicity triggering receptor 1; Natural killer cell p46-related protein; NK cell-activating receptor; NK-p46; CD335; NKp46; NCR1; hNKp46; Lymphocyte antigen 94 homolog |
| 克 隆 号 | |
| 理论分子量 | 55.4 kDa |
| 性 状 | Lyophilized |
| 纯 度 | >90% as determined by SDS-PAGE. |
| 缓 冲 液 | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines. SWISS: O76036 Gene ID: 9437 NKp46是很重要的的自然细胞毒受体，在自然杀伤作用中起关键作用。细胞毒性受体家族（NCRs）主要有：NKp46、NKp44和NKp30，其中NKp46和NKp30表达于所有静止和活化的NK细胞，而NKp44则选择性的表达于活化的NK细胞。靶细胞上的配体分子与NCRs的结合（交联）引发NK细胞的活化导致靶细胞的裂解和大量细胞因子的产生。现已确认NKp46和NKp44可以识别病毒上的配体分子红血球凝聚素，而NKp46则能识别肿瘤细胞上的乙酰硫酸多聚糖。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
