| 产品编号 | bs-104649P |
| 英文名称 | Recombinant Human MICA Protein, C-His |
| 中文名称 | |
| 别 名 | MHC class I polypeptide-related sequence A; MIC-A; MICA; PERB11.1 |
| 克 隆 号 | |
| 理论分子量 | 34.5 kDa |
| 性 状 | Lyophilized |
| 纯 度 | >90% as determined by SDS-PAGE. |
| 缓 冲 液 | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
The MHC class I chain-related (MIC) proteins are related to the Major histocompatibility complex (MHC) class I proteins which are ubiquitously expressed and mediate the recognition of intracellular antigens by cytotoxic T cells. The MHC class I chain-related (MIC) proteins are recognized by NKG2D, a receptor on NK and T cells, and promote anti-tumor activity. MICA, a member of the MIC family, is widely expressed on many tumors, and it is the MICA/NKG2D interaction that is thought to stimulate the anti-tumor reactivity by T lymphocytes. MICA is present in virtually every tissue except the nervous system, suggesting that MIC protein expression may only be one component of the anti-tumor activity of the immune system. SWISS: Q29983 Gene ID: 4276 MICA蛋白是一种细胞应激分子，在正常组织中表达量少，仅在肠道上皮组织表达量稍高，但是在多种肿瘤细胞，尤其是上皮源性的肿瘤如肺癌、乳腺癌、肾癌、卵巢癌、结肠癌等细胞表面高表达，并在细胞发生癌变的早期阶段出现在细胞表面。 该分子与相应受体NKG2D结合后可激活NK细胞、Vd1 gd T细胞、CD8+ T细胞的细胞毒作用，从而产生杀伤肿瘤细胞的生物效应。因此，抗MICA特异性抗体在肿瘤早期诊断、治疗中可能具有更高的敏感性和疗效，从而可实现肿瘤的“早诊断、早治疗”。并且还能对其它治疗方案的疗效进行早期评估。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
