| 产品编号 | bs-104573P |
| 英文名称 | Recombinant Human LYVE1 Protein, N-His-SUMO |
| 中文名称 | |
| 别 名 | Cell surface retention sequence-binding protein 1; XLKD1; LYVE-1; Hyaluronic acid receptor; Extracellular link domain-containing protein 1; CRSBP-1; LYVE1; CRSBP1; HAR; Lymphatic vessel endothelial hyaluronic acid receptor 1 |
| 克 隆 号 | |
| 理论分子量 | 23.89 kDa |
| 性 状 | Lyophilized |
| 纯 度 | >90% as determined by SDS-PAGE. |
| 缓 冲 液 | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
The lymphatic vasculature forms a second circulatory system that drains extracellular fluid from the tissues and provides an exclusive environment in which immune cells can encounter and respond to foreign antigen. Recently a number of interesting molecules have been identified that may be exploited as markers for lymphatic endothelium, including the hyaluronan receptor LYVE1, PALE, VEGFR3, podoplanin. LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. SWISS: Q9Y5Y7 Gene ID: 10894 淋巴管标志物 LYVE-1是一种特异性氨基葡聚糖透明质酸受体，均匀分布在淋巴管的管腔面和基底膜，目前多用于肿瘤淋巴转移方面的研究。 淋巴管内皮细胞透明质酸受体1（LYVE1)LYVE1是位于淋巴管内皮细胞上的含有322个氨基酸残基的膜蛋白。与CD44糖蛋白同源，均匀分布于淋巴管内外腔面，可与细胞外基质的葡萄糖胺聚糖透明质酸结合，具有从组织摄取透明质酸盐并转运至淋巴液的作用。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
