| 产品编号 | bs-104050P |
| 英文名称 | Recombinant Human CYP46A1 Protein, N-His |
| 中文名称 | |
| 别 名 | Cholesterol 24-hydroxylase; Cholesterol 24-monooxygenase; CH24H; CYP46A1; Cytochrome P450 46A1; CYP46; Cholesterol 24S-hydroxylase |
| 克 隆 号 | |
| 理论分子量 | 54.38 kDa |
| 性 状 | Lyophilized |
| 纯 度 | >90% as determined by SDS-PAGE. |
| 缓 冲 液 | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
The Cyp46 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed exclusively in the brain, where it converts cholesterol to 24S-hydroxycholesterol by adding a hydroxyl group to cholesterol, producing a product that is more soluble than cholesterol and able to be exported from the brain.
Cyp46 is also known as 24S-cholesterol hydroxylase. SWISS: Q9Y6A2 Gene ID: 10858 经研究发现CYP46和APOE-4基因都产生变异的人,患老年性痴呆症的风险比正常人高将近10倍，尤其CYP46蛋白控制产生的一种酶,能帮助大脑分解多余的胆固醇;而APOE-4的基因在人体胆固醇的运输过程中起到作用。这说明胆固醇和β-淀粉蛋白的积聚之间也许存在某种关联,人体胆固醇新陈代谢的不足,也可能是导致老年性痴呆症的“罪魁祸首”。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
