| 产品编号 | bs-104046P |
| 英文名称 | Recombinant Human CDK5 Protein, N-His |
| 中文名称 | |
| 别 名 | Cell division protein kinase 5; Cyclin-dependent-like kinase 5; TPKII catalytic subunit; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; CDK5; CDKN5 |
| 克 隆 号 | |
| 理论分子量 | 35.47 kDa |
| 性 状 | Lyophilized |
| 纯 度 | >90% as determined by SDS-PAGE. |
| 缓 冲 液 | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015] SWISS: Q00535 Gene ID: 1020 细胞周期素依赖性激酶-5属于小丝氨酸／苏氨酸周期素依赖性激酶家族成员，虽与其他成员序列具有同源性，但功能却完全不一样，即与细胞周期关系不大，却在中枢神经系统的发育和神经元正常功能的维持中发挥重要作用，并与一些退行性疾病及药物成瘾有密切联系。 CDK-5是神经系统中重要的蛋白激酶之一,周期素依赖性激酶5在神经系统发育过程中,可调节轴突生长、神经元分化及迁移.最近研究表明,周期素依赖性激酶5激酶活性失调与阿尔茨海默病的发病有关. |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
