| 产品编号 | bs-104004P |
| 英文名称 | Recombinant Human NDUFA13 Protein, N-His-SUMO & C-Strep |
| 中文名称 | |
| 别 名 | Gene associated with retinoic and IFN-induced mortality 19 protein; Gene associated with retinoic and interferon-induced mortality 19 protein; CI-B16.6; Cell death regulatory protein GRIM-19; NADH-ubiquinone oxidoreductase B16.6 subunit; GRIM-19; Complex I-B16.6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; GRIM19; NDUFA13 |
| 克 隆 号 | |
| 理论分子量 | 24.9 kDa |
| 性 状 | Lyophilized |
| 纯 度 | >90% as determined by SDS-PAGE. |
| 缓 冲 液 | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
A novel gene, Genes associated with Retinoid IFN induced Mortality (GRIM) GRIM19 gene was identified. Antisense expression of GRIM19 confers a strong resistance against IFN/RA induced death by reducing the intracellular levels of GRIM19 protein. Overexpression of GRIM19 enhances cell death in response to IFN/RA. GRIM19 is primarily a nuclear protein whose expression is induced by the IFN/RA combination. These data indicate that GRIM19 is a novel cell death regulatory molecule. SWISS: Q9P0J0 Gene ID: 51079 GRIM19是GRIMs凋亡相关基因新家族成员之一,是一种由IFN-β联合RA（干扰素/维甲酸）诱导表达的16kDa蛋白,分布在细胞核和胞浆中，GRIM-19是纯化的线粒体呼吸链复合体I的组成成分,这种复合物为ATP合成所必需的,当线粒体复合物I电子转移产生活性,GRIM-19突变体突破线粒体跨膜电位,可增强细胞对凋亡刺激的敏感性，它的过高表达可以抑制肿瘤细胞的增殖，促进细胞的凋亡。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
