| 产品编号 | bs-103586P |
| 英文名称 | Recombinant Human MAP2K4 Protein, N-His |
| 中文名称 | |
| 别 名 | MEK 4; MEK4; SAPK kinase 1; JNKK; c-Jun N-terminal kinase kinase 1; SEK1; JNK-activating kinase 1; MAPK/ERK kinase 4; MAPKK 4; SERK1; SKK1; SAPKK-1; SAPK/ERK kinase 1; PRKMK4; MKK4; MAP kinase kinase 4; MAP2K4; Dual specificity mitogen-activated protein kinase kinase 4; SAPKK1; Stress-activated protein kinase kinase 1; JNKK1 |
| 克 隆 号 | |
| 理论分子量 | 40.01 kDa |
| 性 状 | Lyophilized |
| 纯 度 | >90% as determined by SDS-PAGE. |
| 缓 冲 液 | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] SWISS: P45985 Gene ID: 6416 研究发现---丝裂原活化蛋白激酶激酶4（MKK4）信号途径对肝脏再生具有重要的意义 肝脏是人体最大的内脏器官，承担着数百种功能，包括产生蛋白质与凝血因子，以及促进消化与能量释放等。肝功能衰竭（Liver Failure）是由于肝细胞受到广泛严重的损害，机体代谢功能发生严重紊乱而出现的临床综合征。肝衰竭发生于许多严重的肝脏疾病过程中，症候险恶，预后多不良。 近日，俄勒冈健康与科学大学，加州大学旧金山分校的研究人员介绍了近期一项可用于治疗肝功能衰竭的新成果：研究人员发现 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
