| 产品编号 | bs-103423P |
| 英文名称 | Recombinant Human TIMP2 Protein, N-His |
| 中文名称 | |
| 别 名 | TIMP2; TIMP-2; CSC-21K; Tissue inhibitor of metalloproteinases 2; Metalloproteinase inhibitor 2 |
| 克 隆 号 | |
| 理论分子量 | 23.24 kDa |
| 性 状 | Lyophilized |
| 纯 度 | >90% as determined by SDS-PAGE. |
| 缓 冲 液 | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]. SWISS: P16035 Gene ID: 7077 合成与降解（Synthesis and Degradation） TIMP-2与TIMP-1一样是基质金属蛋白酶的抑制酶，其功能与MMP相反，能抑制肿瘤细胞的浸润和转移，主要用于各种恶性肿瘤如乳腺癌等的研究。TIMP-2又称为CSC-21K，是一种21-24kDa的糖蛋白，在多种组织细胞中表达，它可以和MMPs家族成员以共价键方式形成复合物，从而发挥其抑制作用。在正常生理条件下，MMPs和TIMPs之间的平衡状态是维持细胞外基质正常状态所必需的，一旦它们之间的比例失调，就会造成一系列的病理状态。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
