| 产品编号 |
bs-103274P |
| 英文名称 |
Recombinant Human MASP2 Protein, N-His
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| 中文名称 |
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| 别 名 |
Mannan-binding lectin serine protease 2; Mannose-binding protein-associated serine protease 2; MASP-2; MBL-associated serine protease 2; MASP2 |
| 克 隆 号 |
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| 理论分子量 |
15.63 kDa |
| 性 状 |
Lyophilized |
| 纯 度 |
>90% as determined by SDS-PAGE. |
| 缓 冲 液 |
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 保存条件 |
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
甘露糖结合凝集素(MBL)是补体系统的原有成分,是由肝脏合成的C型凝集素并游离在血清中,也是钙依赖性糖结合蛋白。
MBL可识别和结合病原微生物表面的甘露糖、岩藻糖和N-乙酰葡糖胺等糖结构并首先与病原微生物的糖类配体结合,随后构象发生变化,激活与之相关联的MBL相关的丝氨酸蛋白激酶(MASP),两种MASP(MASP1、MASP2)具有与活化的C1s类似的生物学活性,其中MASP2可水解C4和C2分子,MASP1则可直接切割C3,而形成C3转化酶,以至补体顺序激活,这是补体激活的MBL途径,这种补体
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