| 产品编号 | bs-103193P |
| 英文名称 | Recombinant Human CD150/SLAMF1 Protein, C-His |
| 中文名称 | |
| 别 名 | SLAM family member 1; IPO-3; CDw150; SLAMF1; SLAM; CD150; Signaling lymphocytic activation molecule |
| 克 隆 号 | |
| 理论分子量 | 27.31 kDa |
| 性 状 | Lyophilized |
| 纯 度 | >90% as determined by SDS-PAGE. |
| 缓 冲 液 | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 保存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
SLAM, a novel glycoprotein of 37kDa, designated SLAM (Signaling Lymphocyte Activation Molecule) or CDw150, belongs to the immunoglobulin gene superfamily and is involved in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane bound form of SLAM and the soluble and cytoplasmic isoforms of SLAM, and the expression levels of membrane bound SLAM on B cells are rapidly regulated after activation in vitro. It is suggested that signalling through homophilic SLAM-SLAM binding during B to B and B to T cell interactions enhances the expansion and differentiation of activated B cells. Reports suggest that the extracellular domain of CD150 is the receptor for the measles virus and acts as a co-activator on T cells and B cells. SWISS: Q13291 Gene ID: 6504 CD150（SLAM）为70kD的表面糖蛋白属于免疫球蛋白基因超家族。SLAM有直接诱导CD4阳性T细胞克隆与活化前T细胞的作用。CD150抗原还可以增强抗原特异性增生与通过T细胞携带的CD4抗原产生细胞因子，特别是对干扰素-γ具有极强的上调节作用。SLAM与自身配体具有极高亲和性，由SLAM同源亲和细胞间的相互作用能够刺激T淋巴细胞产生自身因子。CD150抗原还是风疹病毒细胞受体并且通过白介素10下调节。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
