| 产品编号 | bsm-51359M |
| 英文名称 | LRP1B Mouse mAb |
| 中文名称 | LRP1B小鼠单克隆抗体 |
| 别 名 | LDL Receptor Related Protein 1B; Low-Density Lipoprotein Receptor-Related Protein 1B; Low Density Lipoprotein Receptor-Related Protein 1B; LRP-Deleted In Tumors; LRP-DIT; LRP-1B; LRPDIT; Low Density Lipoprotein Receptor Related Protein-Deleted In Tumor; L |
| 研究领域 | 肿瘤 细胞生物 细胞膜受体 |
| 抗体来源 | Mouse |
| 克隆类型 | Monoclonal |
| 克 隆 号 | 2C9 |
| 交叉反应 | (predicted: Human) |
| 产品应用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 516 kDa |
| 检测分子量 | |
| 细胞定位 | 细胞浆 细胞膜 细胞外基质 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | Recombinant Human LRP1B protein |
| 亚 型 | IgG1 |
| 纯化方法 | affinity purified by Protein G |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
LRP1B is a putative tumor suppressor and a member of the low-density lipoprotein (LDL) receptor family. The LDL receptor family have roles related to clearance of extracellular ligand and are proposed to be involved in extracellular signal transduction. silencing and down-expression of LRP1B as been observed in renal cell carcinoma and thyroid cancer. Further Deletion of LRP1B has been associated with chemotherapy resistance in high-grade serous cancers. Function: Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. Subunit: Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is followed by internalization and degradation of the ligands. Subcellular Location: Membrane; Single-pass type I membrane protein Tissue Specificity: Expressed in thyroid gland and in salivary gland, as well as in adult and fetal brain. Similarity: Belongs to the LDLR family. SWISS: Q9NZR2 Gene ID: 53353 Database links: Entrez Gene: 53353 Human SwissProt: Q9NZR2 Human |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
