| 产品编号 | bs-0474P-APC |
| 英文名称 | Human IgA Native protein / APC |
| 中文名称 | APC标记的人免疫球蛋白A |
| 别 名 | Human IgA protein; Human IgA; Purified Human IgA; 天然人IgA蛋白/人免疫球蛋白A |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 保存条件 | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 产品介绍 |
Human IgA (immunoglobulin A) is a glycosylated protein of 160 kDa and is produced as a monomer or as a J chain linked dimer. Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA. OR: The secretory component is a component of immunoglobulin A (IgA) which consists of a portion of the polymeric immunoglobulin receptor. Polymeric IgA binds to the polymeric immunoglobulin receptor on the basolateral surface of epithelial cells and is taken up into the cell via transcytosis. The receptor-IgA complex passes through the cellular compartments before being secreted on the luminal surface of the epithelial cells, still attached to the receptor. Proteolysis of the receptor occurs and the dimeric IgA molecule, along with the secretory component, are free to diffuse throughout the lumen. 血清型IgA是单体（bs-0474P），分泌型IgA是双聚体（bs-0360P） IgA分为血清型和分泌型两种类型 大部分血清IgA为单体，大约10%～15%为双聚体，也发现少量多聚体。IgA功能区的分布与IgG十分相似，两个亚类（IgA1和IgA2）的最大差异在铰链区。IgA2缺少H-L链间二硫键区域，容易被解离分开。从含量、稳定性和半衰期看，血清型IgA虽不如IgG，但高于其他类Ig.IgA可以结合抗原，但不能激活补体的经典途径，因此不能象IgG那样发挥许多的生物效应，所以过去曾误以为血清型IgA的意 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
