| 产品编号 | D51012 |
| 英文名称 | NSC319726 |
| 中文名称 | |
| 别 名 | Mutant p53激活剂 |
| 克 隆 号 | |
| CAS | 71555-25-4 |
| 理论分子量 | 234.32 kDa |
| 检测分子量 | |
| 性 状 | Lyophilized |
| 保存条件 | Store in dry, dark place for one year. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
NSC319726 is a potent and selective activator of mutant p53R175 (EC50 ~8 nM in mutant p53 cell lines but with >100-fold selectivity in wild type cells). It has potent growth inhibitory activity in mutant p53 cells, particularly for the p53R175 mutant. Mechanistic studies revealed that NSC319726 restores WT structure and function to the p53R175 mutant. It kills p53R175H knock-in mice with extensive apoptosis and inhibits xenograft tumor growth in a 175-allele-specific mutant p53-dependent manner. This activity depends upon the zinc ion chelating properties of the compound as well as redox changes. NSC319726 is an attractive lead compound for anti-cancer drug development. |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
