| 产品编号 | D50955 |
| 英文名称 | SW033291 |
| 中文名称 | |
| 别 名 | 15-PGDH抑制剂 |
| 克 隆 号 | |
| CAS | 459147-39-8 |
| 理论分子量 | 412.59 kDa |
| 检测分子量 | |
| 性 状 | Lyophilized |
| 保存条件 | Store in dry, dark place for one year. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
SW033291 is a highly potent and selective inhibitor of 15-PGDH enzyme with IC50 1.5 nM, can increase prostaglandin PGE2 levels in bone marrow and other tissues. It inhibits 15-PGDH with noncompetitive pattern. Treatment of A549 cells with SW033291 increased PGE2 levels by 3.5-fold at 500 nM, with EC50 value of ~75 nM. SW033291 accelerates hematopoietic recovery in mice receiving a bone marrow transplant. It also promotes tissue regeneration in mouse models of colon and liver injury. Tissues from 15-PGDH knockout mice demonstrate similar increased regenerative capacity. SW033291is a good compound to validate 15-PGDH inhibition could be a new therapeutic strategy for tissue regeneration in diverse clinical contexts. |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
