| 产品编号 | D50920 |
| 英文名称 | VLX600 |
| 中文名称 | |
| 别 名 | Mitochondrial OXPHOS抑制剂 |
| 克 隆 号 | |
| CAS | 327031-55-0 |
| 理论分子量 | 317.35 kDa |
| 检测分子量 | |
| 性 状 | Lyophilized |
| 保存条件 | Store in dry, dark place for one year. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
VLX600 is a potent and selective mitochondrial OXPHOS inhibitor. It is preferentially active against quiescent cells in colon cancer 3-D microtissues (low micromole activity). The anticancer activity is associated with reduced mitochondrial respiration, leading to bioenergetic catastrophe and tumour cell death. VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation. It induces the expression of genes associated with hypoxia, glycolysis, and p53 signaling, stimulates autophagy, and triggers mitochondrial dysfunction in MCs. It displays antitumor activity against colon cancer xenografts with minimal systemic toxicity in mice. Right now it is in phase I clinical trials for patients with refractory advanced solid tumors. |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
