| 产品介绍 |
SD70 is a potent, selective and cell-permeable inhibitor of histone demethylase JMJD2 (KDM4C), identified by phenotypic screening for inhibitors of ligand and genotoxic stress-induced translocations in prostate cancer cells. Through Chem-seq approach, SD70 was found to inhibit the androgen-dependent AR program and prostate cancer cell growth, acting, at least in part, by functionally inhibiting the Jumonji domain-containing demethylase KDM4C. SD70 inhibits AR target gene expression, inhibits prostate cancer cell growth in vitro and tumor growth in vivo. SD70 holds potential promise for ultimate use in prostate cancer therapy.
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