| 产品编号 | D50852 |
| 英文名称 | CI994 (Tacedinaline) |
| 中文名称 | |
| 别 名 | HDAC抑制剂 |
| 克 隆 号 | |
| CAS | 112522-64-2 |
| 理论分子量 | 269.3 kDa |
| 检测分子量 | |
| 性 状 | Lyophilized |
| 保存条件 | Store in dry, dark place for one year. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
CI994 is a potent, selective and orally active histone deacetylase (HDAC) inhibitor. It inhibits HDAC1 (IC50 ~0.57 μM), HDAC2 (IC50 ~0.90 μM) and HDAC3 (IC50 ~1.2 μM). It does not inhibit HDAC6 and HDAC8 (IC50 >100 μM). CI994 mediates G1 cell cycle arrest, inhibits proliferation, and induces apoptosis in tumor cell lines. It has also demonstrated antitumor activity in several tumor models, including the chemo-resistant mouse pancreatic ductal carcinoma as well as the human prostate tumor model LNCaP. Currently CI994 is in phase III clinical trials for lung cancer. In recent publication CI994 could also epigenetically prime the hippocampal transcriptome for reinstated neuroplasticity and lead to increased neuroplasticity during memory extinction. This suggests applying HDACis during memory reconsolidation might constitute a treatment option for remote traumata. |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
