| 产品编号 | D50842 |
| 英文名称 | RG108 |
| 中文名称 | |
| 别 名 | DNA Methyltransferase抑制剂 |
| 克 隆 号 | |
| CAS | 48208-26-0 |
| 理论分子量 | 334.33 kDa |
| 检测分子量 | |
| 性 状 | Lyophilized |
| 保存条件 | Store in dry, dark place for one year. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
RG108 is a potent, selective and cell permeable inhibitor of DNA methyltransferase. Unlike 5-azaC, RG108 is not a nucleoside and therefore does not modify DNA. It binds to the enzyme active site and inhibits DNMT enzymatic activity with an IC50 ~ 115 nM. It inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Treatment with RG108 results in the demethylation of genomic DNA and can reactivate epigenetically silenced tumor suppressor genes. It has been shown to improve the reprogramming efficiency of mouse embryonic fibroblasts (MEFs) into induced pluripotent stem (iPS) cells. RG108 can potentially be used to maintain embryonic stem (ES) cells in an undifferentiated state as well as replace transcription factors in both mouse and human cell reprogramming. |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
