| 产品编号 | D50786 |
| 英文名称 | AR7 |
| 中文名称 | |
| 别 名 | RARα拮抗剂 |
| 克 隆 号 | |
| CAS | 80306-38-3 |
| 理论分子量 | 257.71 kDa |
| 检测分子量 | |
| 性 状 | Lyophilized |
| 保存条件 | Store in dry, dark place for one year. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
AR7 was developed as a highly potent and selective enhancer of the chaperone-mediated autophagy (CMA) through antagonizing RARα. It is a synthetic derivative of all-trans-retinoic acid developed through the structure-based chemical design. CMA contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. A decrease in CMA activity occurs in aging and in age-related disorders (such as neurodegenerative diseases and diabetes). AR7 is the first small molecule developed to selectively stimulate CMA without affecting macroautophagy. Importantly, AR7 was shown to protect cells from oxidative stress and proteotoxicity, presenting a potential therapeutic strategy against cellular dysfunction and disease resulted from reduced CMA. |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
