| 产品编号 | D50706 |
| 英文名称 | Wnt-C59 |
| 中文名称 | |
| 别 名 | Wnt拮抗剂 |
| 克 隆 号 | |
| CAS | 1243243-89-1 |
| 理论分子量 | 379.45 kDa |
| 检测分子量 | |
| 性 状 | Lyophilized |
| 保存条件 | Store in dry, dark place for one year. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. It prevents palmitylation of Wnt proteins by Porcupine (a membrane-bound O-acyltransferase), thereby blocking Wnt protein secretion and activity. Wnt-C59 displayed good bioavailability as once daily oral administration and blocked progression of mammary tumors in MMTV-WNT1 transgenic mice model while downregulating Wnt/β-catenin target genes. Because Wnt-C59 exhibits much better potency and selectivity than the reported IWP series of Porcupine/Wnt inhibitors, it serves as the better Wnt pathway inhibitor for in vitro and in vivo studies. |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
