| 产品编号 |
D50806 |
| 英文名称 |
SKP2-C25
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| 中文名称 |
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| 别 名 |
3-(1,3-Benzothiazol-2-yl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-chromen-4-one; 4H-1-Benzopyran-4-one, 3-(2-benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-; 3-(1,3-benzothiazol-2-yl)-6-ethyl-7-hydroxy-8-(piperidin-1-ylmethyl)-4H-chromen-4-one; SZL-P1-41; SZL P1 41; SZLP141; SKP2 E3 Ligase Inhibitor III . Skp2抑制剂 |
| 克 隆 号 |
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| CAS |
222716-34-9 |
| 理论分子量 |
420.52 kDa |
| 检测分子量 |
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| 性 状 |
Lyophilized |
| 保存条件 |
Store in dry, dark place for one year. |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
SKP2-C25 is a potent, selective and cell permeable Skp2 inhibitor. It selectively inhibits Skp2 E3 ligase activity, but not activity of other SCF complexes. It also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival and Akt-mediated glycolysis and triggering p53-independent cellular senescence. SKP2-C25 exhibits potent antitumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival. It is a useful chemical probe to target Skp2, which is a promising target for restricting cancer stem cell and cancer progression.
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