| 产品编号 |
D51115 |
| 英文名称 |
BLU-9931
|
| 中文名称 |
|
| 别 名 |
blu9931; 2-Propenamide, N-[2-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]-3-methylphenyl]-; N-(2-{[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino}-3-methylphenyl)acrylamide; BLU-9931; 1538604-68-0; FGFR4抑制剂 |
| 克 隆 号 |
|
| CAS |
1538604-68-0 |
| 理论分子量 |
509.38 kDa |
| 检测分子量 |
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| 性 状 |
Lyophilized |
| 保存条件 |
Store in dry, dark place for one year. |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
BLU-9931 is a potent and irreversible small-molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU-9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU-9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor xenograft that overexpresses FGF19 mRNA but lacks FGF19 amplification. Approximately one third of patients with HCC whose tumors express FGF19 together with FGFR4 and its coreceptor klotho β (KLB) could potentially respond to treatment with an FGFR4 inhibitor.
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