| 产品编号 |
bs-43206P |
| 英文名称 |
Recombinant mouse FCGRT&B2M Heterodimer protein, C-His (HEK293)
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| 中文名称 |
重组小鼠 FCGRT & B2M Heterodimer 蛋白 |
| 理论分子量 |
33 kDa |
| 检测分子量 |
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| 性 状 |
Lyophilized or Liquid |
| 浓 度 |
>0.5mg/ml |
| 物 种 |
Mouse |
| 纯 度 |
>90% as determined by SDS-PAGE |
| 内毒素 |
Not analyzed |
| 表达系统 |
HEK293 cell |
| 标签 |
C-His |
| 缓 冲 液 |
PBS (pH7.4) |
| 保存条件 |
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
FcRN present in the intestinal epithelium of neonatal mice and rats mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn animals to acquire passive immunity. FcRn (also designated FCGRT, Brambell receptor, FcRn å chain, IgG Gc receptor and neonatal Fc-receptor) is comprised of a heavy chain and ∫-2-Microglobulin. FcRn heavy chain shows approximately 35% amino acid identity to an MHC class I molecule. FcRN localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal catabolism. This protection mechanism is a major constituent for ensuring IgG are the longest lived of all plasma proteins.
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| 产品图片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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