| 产品编号 | V3704 |
| 英文名称 | Human sST2 |
| 中文名称 | 人生长抑素受体2单克隆抗体 |
| 别 名 | somatostatin receptor 2; Somatostatin receptor type 2; SRIF1; SS2R; SST2; SSTR2; SRIF-1; SS-2-R; SS2-R; SSR2_HUMAN. |
| 克 隆 号 | 8H7 |
| 理论分子量 | 41kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 缓 冲 液 | PBS (pH=7.4) |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
Somatostatin is a tetradecapeptide that is widely distributed in the body and is one of five receptor subtypes termed SSTr1-. These receptors function in the regulation of numerous phsiological processes such as the secretion of insulin, glucagon and growth hormone as wel as cell growth induced by neuronal excitation in both the central and peripheral nervous systems. Somatostatin receptos are activated via sonatostatin secreted by nerve and endocrine cells. Somatostatin Receptor 2 (SSR2), along with SSR1, is expressed at the highest levels in the stomach and jejunum, cerebrum and kidney, respectively. Function: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels. Subunit: The C-terminus interacts with SHANK1 PDZ domain. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Cerebrum and kidney. In lesser amounts in jejunum, colon and liver. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P30874 Gene ID: 6752 Database links: Entrez Gene: 6752 Human Entrez Gene: 20606 Mouse Omim: 182452 Human SwissProt: P30874 Human SwissProt: P30875 Mouse Unigene: 514451 Human Unigene: 454968 Mouse Unigene: 202974 Rat Unigene: 9929 Rat SSTR2的表达在肿瘤的分布、发生和发展中起重要作用。目前主要用于肿瘤方面的研究。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
