| 产品编号 | bs-42094P |
| 英文名称 | Recombinant mouse STING1 protein, N-His |
| 中文名称 | 重组小鼠跨膜蛋白173 |
| 别 名 | Endoplasmic reticulum interferon stimulator; Mediator of IRF3 activation; Mitochondrial mediator of IRF3 activation; N terminal methionine proline tyrosine serine plasma membrane tetraspanner; Stimulator of interferon genes; Stimulator of interferon genes |
| 理论分子量 | 24.4 kDa |
| 检测分子量 | |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | >0.5mg/ml |
| 物 种 | Mouse |
| 序 列 | 215-378/378 |
| 纯化方法 | AC |
| 表达系统 | E.coli |
| 标签 | N-His |
| 缓 冲 液 | 20mM Tris-HCl (pH8.0). |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014] STING由379个氨基酸构成，有数个跨膜结构域，在多种内皮细胞、上皮细胞中以及造血肝细胞均有表达。STING参与并促进DNA介导的先天免疫反应，即来自病毒和细菌的非CpG双链DNA与cGAS蛋白结合后被催化成第二信使cGAMP；接着二聚化的STING与cGAMP结合，发生构象变化，通过自噬小体（autophagsome）经内质网和高尔基体进一步进入细胞质，期间被泛素化后募集TBK1蛋白，再被磷酸化，之后与IRF3结合；接着IRF3被磷酸化后入核，诱导表达IFNs，细胞因子、T细胞募集因子等进而增强机体的免疫能力，更大限度的杀伤细菌，病毒等病原体。 |
| 产品图片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
